St. Anne is located at 560 Oak Ridge Turnpike which is on the East end of Oak Ridge.
Take exit 376A off of I-40 onto 162 North/Oak Ridge (also known as the Pellissippi Parkway). Continue on the Pellissippi Parkway about 6 miles through the town of Solway, following the signs for Oak Ridge. (Route 162 becomes 62 after Solway, then S. Illinois Avenue in Oak Ridge.) After leaving Solway, stay in the center or left lane to avoid turning early. As you come into Oak Ridge, make the first right you can (onto LaFayette Drive). The Y-12 Federal Credit Union is on the right corner.
You will be on LaFayette for 1.5 miles, 4 traffic lights. At the 4th light, which is the intersection of Oak Ridge Turnpike and LaFayette, make a right turn onto the Oak Ridge Turnpike. Go approximately 1.5 miles on the Turnpike. Just past the intersection of Fairbanks/Florida traffic light, be in the center lane, looking for the left turn into the Church parking lot. Parking is available in front of the church, with more room in the back lot as well.
From the Clinton/Norris area (northeast of the Church)
From I-75 Exit 122, head west toward Clinton on TN-61 WEST. Go approximately 12 miles. As you enter Oak Ridge this becomes Oak Ridge Turnpike. Continue for another 2.5 miles (two traffic lights). St Anne will be on your right.
The Scenic Route
Leaving church, here is an alternate route back to Knoxville. This way is a little longer, but offers pretty views of Melton Hill Lake and the greenery around it. Make a left out of the church parking lot onto Oak Ridge Turnpike. Go 1.4 miles, through the Arkansas traffic light; at the next light, make the right onto Melton Lake Drive. Follow Melton Lake 3.5 miles. At the T-intersection, make the right onto 170 West (Edgemoor Road). [If you use these directions in reverse, there is a ramp (jug handle) for making the left off of Edgemoor Road onto Melton Lake Drive.] In 2.5 miles you will come to where Route 62 splits left for Knoxville and right for Oak Ridge. Make the left through Solway and continue east on 162 (Pellissippi Parkway) toward Knoxville and (for the airport) Maryville/Alcoa.